Reaction: GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
- in pathway: Class A/1 (Rhodopsin-like receptors)
The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. This was later replaced by reports that OGR1 and GPR4 sense acidic pH. GPR4, OGR1, and TDAG8 are now considered as proton-sensing receptors.
Reaction - small molecule participants:
H+ [extracellular region]
Reactome.org reaction link: R-HSA-444731
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Reaction input - small molecules:
hydron
Reaction output - small molecules:
Reactome.org link: R-HSA-444731