Reaction: Phosphorylation of L1 by ERK
- in pathway: Recycling pathway of L1
L1 cross linking can activate MAPK cascade components MEK1/2, ERK1/2, as well as Src, Raf-1,and p90rsk. MAP kinase signaling requires endocytosis mediated by Src. ERK2 can phos-phorylate internalized L1 at serine residues 1204 and 1248. This phosphorylation may increase the neurite growth.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-445079
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-445079