Reaction: Phosphorylation of VAV2
- in pathway: Signal transduction by L1
L1 crosslinking leads to the tyrosine phosphorylation and activation of VAV2. Tyr-172 in VAV2 binds to the DBL homology region autoinhibiting its GEF-activity. Tyrosine kinase src may phosphorylate this residue and relieve the autoinhibition.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-445085
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-445085