Reaction: DOLPP1 dephosphorylates DOLDP to DOLP
- in pathway: Synthesis of Dolichyl-phosphate
In the last step of the N-glycan precursor biosynthesis pathway, the mature N-glycan (Glc3Man9GlcNAc2) is removed from the dolichyl diphosphate (DOLDP) molecule upon which it has been synthesized and attached to a nascent protein. The released DOLDP molecule is de-phosphorylated by dolichyl diphosphatase 1 (DOLPP1) to dolichyl phosphate (DOLP). DOLP is thus salvaged and be used as substrate for the synthesis of another N-glycan oligosaccharide (Wedgwood & Strominger 1980).
Reaction - small molecule participants:
Pi [cytosol]
DOLP [integral component of cytoplasmic side of endoplasmic reticulum membrane]
H2O [cytosol]
DOLDP [integral component of cytoplasmic side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-446200
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Reaction input - small molecules:
water
dolichyl diphosphate
Reaction output - small molecules:
hydrogenphosphate
dolichyl phosphate(2-)
Reactome.org link: R-HSA-446200