Reaction: PMM1,2 isomerise Man6P to Man1P
- in pathway: Synthesis of GDP-mannose
Phosphomannomutases 1 and 2 (PMM1 and PMM2) catalyse the isomerisation of mannose 6-phosphate (Man6P) to mannose 1-phosphate (Man1P) in the cytosol of cells (Wada & Sakamoto 1997, Matthijs et al. 1997). Mutations in the PMM2 gene are one of the causes of Jaeken syndrome. a disease of glycosylation, type CDGIa. (Matthijs et al. 1997b).
Reaction - small molecule participants:
Man1P [cytosol]
Man6P [cytosol]
Reactome.org reaction link: R-HSA-446201
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Reaction input - small molecules:
D-mannose 6-phosphate
Reaction output - small molecules:
alpha-D-mannose 1-phosphate
Reactome.org link: R-HSA-446201