Reaction: Addition of the first glucose to the N-glycan precursor by ALG6
- in pathway: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
The first glucose is added to the N-glycan precursor, mediated by ALG6. Defects in ALG6 are associated with CDG-Ic disorder (Imbach T et al, 1999; Sun L et al, 2005). The donor is a dolichol-phosphate-glucose (synthesized by ALG5).
Reaction - small molecule participants:
DOLP [integral component of lumenal side of endoplasmic reticulum membrane]
(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane]
(GlcNAc)2 (Man)9 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane]
DbGP [integral component of lumenal side of endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-446202
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Reaction input - small molecules:
alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-alpha-GlcNAc(PP-Dol)
dolichyl beta-D-glucosyl phosphate
Reaction output - small molecules:
dolichyl phosphate(2-)
alpha-Gal-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-alpha-GlcNAc(PP-Dol)
Reactome.org link: R-HSA-446202