Reaction: GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine
- in pathway: Synthesis of UDP-N-acetyl-glucosamine
Cytosolic UAP1 catalyzes the reaction of N-acetyl-D-glucosamine 1-phosphate (GlcNAc1P) and UTP to UDP-N-acetyl-D-glucosamine and pyrophosphate. Structural studies indicate that the active form of the enzyme is a dimer (Peneff C et al, 2001).
Reaction - small molecule participants:
PPi [cytosol]
UDP-GlcNAc [cytosol]
UTP [cytosol]
AcGlcN1P [cytosol]
Reactome.org reaction link: R-HSA-446204
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Reaction input - small molecules:
UTP(4-)
N-acetyl-alpha-D-glucosamine 1-phosphate(2-)
Reaction output - small molecules:
diphosphate(3-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
Reactome.org link: R-HSA-446204