Reaction: AMPK phosphorylates Raptor in the mTORC1 complex
- in pathway: Energy dependent regulation of mTOR by LKB1-AMPK
Activated AMPK (phosphorylated on Thr172 or Thr174 and AMP bound) phosphorylates RPTOR (Raptor) on Ser722 and Ser792. These phosphorylations are required for inhibition of mTORC1 activity in response to energy stress (Gwinn et al. 2008).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-447074
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-447074