Reaction: Acetylation of glucosamine 6-phosphate to GlcNAc6P
- in pathway: Synthesis of UDP-N-acetyl-glucosamine
Cytosolic GNPNAT1 catalyzes the reaction of glucosamine 6-phosphate and acetyl-CoA to form N-acetyl-glucosamine 6-phosphate (GlcNAc6P) and CoA-SH. Structural studies indicate that the active form of the enzyme is a dimer (Wang J et al, 2008).
Reaction - small molecule participants:
CoA-SH [cytosol]
AcGlcN6P [cytosol]
Ac-CoA [cytosol]
GlcN6P [cytosol]
Reactome.org reaction link: R-HSA-449734
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Reaction input - small molecules:
acetyl-CoA(4-)
alpha-D-glucosamine 6-phosphate
Reaction output - small molecules:
coenzyme A(4-)
N-acetyl-D-glucosamine 6-phosphate(2-)
Reactome.org link: R-HSA-449734