Reaction: acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
- in pathway: Ethanol oxidation
ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
Ac-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
ATP [mitochondrial matrix]
CH3COO- [mitochondrial matrix]
Reactome.org reaction link: R-HSA-449911
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Reaction input - small molecules:
coenzyme A(4-)
ATP(4-)
acetate
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
acetyl-CoA(4-)
Reactome.org link: R-HSA-449911