Reaction: pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
- in pathway: Pyrophosphate hydrolysis
Mitochondrial PPA2 (pyrophosphatase (inorganic) 2) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme requires Mg++ for activity (Curbo et al. 2006). The enzyme is inferred to be a homodimer by analogy to its cytosolic isoform.
Reaction - small molecule participants:
Pi [mitochondrial matrix]
PPi [mitochondrial matrix]
H2O [mitochondrial matrix]
Pi [mitochondrial matrix]
PPi [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-449937
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Reaction input - small molecules:
diphosphate(3-)
water
diphosphate(3-)
water
Reaction output - small molecules:
hydrogenphosphate
hydrogenphosphate
Reactome.org link: R-HSA-449937