Reaction: MK2 phosphorylates ZFP36 (Tristetraproline, TTP)
- in pathway: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
TTP is phosphorylated by MK2 at serines 60 and 186.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-450463
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-450463