Reaction: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.
- in pathway: Interleukin-1 signaling
IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.
Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6.
Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-450827
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-450827