Reaction: NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]
- in pathway: Citric acid cycle (TCA cycle)
NNT (nicotinamide nucleotide transhydrogenase) associated with the inner mitochondrial membrane catalyzes the reaction of mitochondrial NADPH and NAD+ to form NADP+ and NADH. The reaction is coupled to the translocation of a proton across the inner mitochondrial membrane into the mitochondrial matrix (White et al, 2000). The active form of NNT is inferred to be a homodimer based on the known structure of its bovine homolog (Yamaguchi and Hatefi 1991).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
H+ [mitochondrial matrix]
NADH [mitochondrial matrix]
H+ [cytosol]
NAD+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-450971
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Reaction input - small molecules:
hydron
NAD(1-)
NADPH
Reaction output - small molecules:
NADP(+)
hydron
NADH(2-)
Reactome.org link: R-HSA-450971