Reaction: isocitrate <=> citrate
- in pathway: Citric acid cycle (TCA cycle)
Mitochondrial aconitase reversibly converts isocitrate to citrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).
Reaction - small molecule participants:
CIT [mitochondrial matrix]
ISCIT [mitochondrial matrix]
Reactome.org reaction link: R-HSA-450975
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Reaction input - small molecules:
D-threo-isocitrate(3-)
Reaction output - small molecules:
citric acid
Reactome.org link: R-HSA-450975