Reaction: (S)-Malate <=> Fumarate + H2O
- in pathway: Citric acid cycle (TCA cycle)
Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).
Reaction - small molecule participants:
FUMA [mitochondrial matrix]
H2O [mitochondrial matrix]
MAL [mitochondrial matrix]
Reactome.org reaction link: R-HSA-451033
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Reaction input - small molecules:
(S)-malate(2-)
Reaction output - small molecules:
fumaric acid
water
Reactome.org link: R-HSA-451033