Reaction: PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex
- in pathway: Glycogen breakdown (glycogenolysis)
Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).
Reaction - small molecule participants:
AMP [cytosol]
Reactome.org reaction link: R-HSA-453342
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Reaction input - small molecules:
adenosine 5'-monophosphate(2-)
Reaction output - small molecules:
Reactome.org link: R-HSA-453342