Reaction: VANGL2 is phosphorylated in response to WNT5A
- in pathway: PCP/CE pathway
Based on studies in mouse, human VANGL2 is predicted to be phosphorylated and activated in response to WNT5A, possibly by CK1delta. Phosphorylation occurs on serine and threonine residues in 2 clusters and appears to be primed by phosphorylation at S5, S82 and S84. VANGL2 phosphorylation and activation occurs in a graded fashion in response to WNT5A distribution, helping to establish PCP asymmetry (Gao et al, 2011).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-4551570
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-4551570