Reaction: USP8 deubiquitinates FZD to potentiate WNT signaling
- in pathway: Regulation of FZD by ubiquitination
USP8 is a deubiquitinase that enhances WNT signaling by deubiquitinating the FZD receptor and promoting its recycling to the cell surface (Mukai et al, 2010).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-4641236
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-4641236