Reaction: CTNNB1 S33 mutants aren't phosphorylated by GSK3beta
- in pathway: CTNNB1 S33 mutants aren't phosphorylated
S33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S33 mutations have been identified in cancers of the central nervous system, liver, endometrium and stomach, among others (reviewed in Polakis, 2000).
Reaction - small molecule participants:
ATP [cytosol]
Reactome.org reaction link: R-HSA-4839634
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-4839634