Reaction: CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
- in pathway: CTNNB1 S37 mutants aren't phosphorylated
S37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S37 mutations have been identified in cancers of the brain, liver, ovary and large intestine, among others (reviewed in Polakis, 2000).
Reaction - small molecule participants:
ATP [cytosol]
Reactome.org reaction link: R-HSA-4839635
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-4839635