Reaction: CTNNB1 T41 mutants aren't phosphorylated by GSK3beta
- in pathway: CTNNB1 T41 mutants aren't phosphorylated
T41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Polakis, 2012). T41 mutations have been identified in cancers of the liver and brain, as well as in the pituitary, endometrium, large intestine and skin, among others (reviewed in Polakis, 2000; Saito-Diaz et al, 2013).
Reaction - small molecule participants:
ATP [cytosol]
Reactome.org reaction link: R-HSA-4839638
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-4839638