Reaction: DVL2 is phosphorylated by PKC
- in pathway: WNT5A-dependent internalization of FZD4
WNT5A-dependent phosphorylation of DVL2 by PKC is required for the internalization of FZD4 (Chen et al, 2003; Yu et al, 2007). Endogenous PKC alpha beta and gamma co-immunoprecipitate with myc-DVL2, and phosphorylation increases the association with beta-arrestin 2 (ARRB2) (Chen et al, 2003).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5138432
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5138432