Reaction: SIRT1 deacetylates TAF1B in SL1 complex
- in pathway: SIRT1 negatively regulates rRNA expression
As inferred from mouse, SIRT1, an NAD+ dependent deacetylase, deacetylates the TAF1B (TAF(1)68) subunit of the SL1 complex. Deacetylation of TAF1B inhibits transcription of rRNA genes.
Reaction - small molecule participants:
NAM [nucleoplasm]
2'-O-acetyl-ADP-ribose [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-5211239
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
2''-O-acetyl-ADP-D-ribose
Reactome.org link: R-HSA-5211239