Reaction: PKC autophosphorylates
- in pathway: VEGFR2 mediated cell proliferation
After phosphorylation by PDK1, PKC undergoes autophosphorylation at two sites important for PKC activity, one in the turn motif (Thr-642 in PKCB) and the second in the hydrophobic phosphorylation motif (Ser-661 in PKCB). These phosphorylations render the enzyme catalytically competent but still inactive; diacylglycerol (DAG) and calcium are required for full activation.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5218805
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5218805