Reaction: FYN autophosphorylates
- in pathway: VEGFA-VEGFR2 Pathway
FYN recruited to VEGFR2 is activated; this is required for VEGF-induced actin remodelling and endothelial migration. Once Y531 in the negative regulatory site is dephosphorylated by a phosphatase, FYN undergoes autophosphorylation on Y420 (Yeo et al. 2011).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5218806
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5218806