Reaction: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
- in pathway: VEGFA-VEGFR2 Pathway
Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5218826
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5218826