Reaction: p-MAPK2/3 phosphorylates HSP27
- in pathway: VEGFA-VEGFR2 Pathway
Activated MAP kinase-activated protein kinase (MAPK/MAPKAPK) 2 and 3 in turn phosphorylate heat shock protein beta 1 (HSPB1, HSP27). HSP27 is an actin-capping protein. Its phosphorylation has been proposed to release it from actin filaments, thus allowing addition of actin monomers and elongation of filaments. Phosphorylation-induced conformational changes causes disaggregation of oligomeric complexes of HSP27 and subsequent disassociation from actin filaments, which may result in a higher rate of actin polymerization (Lamalice et al. 2007, Rousseau et al. 2000, Lavoie et al. 1995).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5218916
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5218916