Reaction: TDG excises 5-carboxylcytosine
- in pathway: TET1,2,3 and TDG demethylate DNA
Thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5-caC) from DNA (Maiti and Drohat 2011, Hashimoto et al. 2012, Zhang et al. 2012, inferred from mouse in He et al. 2011) by flipping the base out of the helix and cleaving the N-glycosidic bond to leave an abasic site (apurinic/apyrimidinic site, AP site) (Hashimoto et al. 2012, Zhang et al. 2012). TDG interacts with the G opposite the excised base and remains bound to the abasic site (Maiti et al. 2008). Dissociation of TDG from DNA is the rate-limiting step of the reaction.
Reaction - small molecule participants:
5-caC [nucleoplasm]
Reactome.org reaction link: R-HSA-5221061
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Reaction input - small molecules:
Reaction output - small molecules:
5-carboxycytosine
Reactome.org link: R-HSA-5221061