Reaction: LPIN catalyzes conversion of phosphatidic acid to diacylglycerol
- in pathway: Depolymerization of the Nuclear Lamina
Lipin proteins LPIN1, 2, and 3, associated with the nuclear envelope, can each catalyze the hydrolysis of phosphatidate to yield 1,2-diacyl-glycerol and orthophosphate. The activities of LPIN1 and LPIN2 have been established experimentally (Grimsey et al. 2008); that of LPIN3 is inferred from its structural similarities both to its human paralogues and to its mouse ortholog (Donkor et al. 2007).
Reaction - small molecule participants:
Pi [nucleoplasm]
DAG [nuclear envelope]
H2O [nucleoplasm]
1,2-diacyl-glycerol 3-phosphate [nuclear envelope]
Reactome.org reaction link: R-HSA-5221130
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Reaction input - small molecules:
water
1,2-diacyl-sn-glycerol 3-phosphate
Reaction output - small molecules:
hydrogenphosphate
1,2-diacyl-sn-glycerol
Reactome.org link: R-HSA-5221130