Reaction: tetX HC transports tetX LC from target cell endosome membrane into cytosol
- in pathway: Toxicity of tetanus toxin (tetX)
Acidification of the vesicle containing tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) is inferred to cause a conformational change in the toxin dimer, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol (Montal 2010).
Reaction - small molecule participants:
GD3 [endocytic vesicle membrane]
GM1a [endocytic vesicle membrane]
Reactome.org reaction link: R-HSA-5228406
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Reaction input - small molecules:
Reaction output - small molecules:
alpha-Neu5NAc-(2->8)-alpha-Neu5NAc-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer
alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine
Reactome.org link: R-HSA-5228406