Reaction: tetX HC:LC binds target cell-surface gangliosides
- in pathway: Toxicity of tetanus toxin (tetX)
Tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) binds gangliosides on the plasma membrane of a human target cell (Chen et al. 2009; Deinhardt et al. 2006).
Reaction - small molecule participants:
GD3 [plasma membrane]
GM1a [plasma membrane]
Reactome.org reaction link: R-HSA-5228407
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Reaction input - small molecules:
alpha-Neu5NAc-(2->8)-alpha-Neu5NAc-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer
alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine
Reaction output - small molecules:
Reactome.org link: R-HSA-5228407