Reaction: Depolymerization of lamin filaments after PKC-mediated phosphorylation
- in pathway: Depolymerization of the Nuclear Lamina
Protein kinase C (PRKCA and PRKCB), activated by lipin-generated diacylglycerol (DAG), phosphorylates C-terminal tails of lamins (serine S395 in lamins A, B and C, and also serine S405 of lamin B), leading to depolymerization of lamin filaments (Hocevar et al. 1993, Goss et al. 1994, Mall et al. 2012).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5229194
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5229194