Reaction: LCN2:2,5DHBA binds Fe3+
- in pathway: Iron uptake and transport
Neutrophil gelatinase associated lipocalin (LCN2, NGAL) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells. LCN2 binds iron via an association with 2,5 dihydroxybenzoic acid (2,5DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell via interacting with different receptors, depending on cellular requirement (Goetz et al. 2002, Devireddy et al. 2010). LCN2 is a potent bacteriostatic agent in iron limiting conditions therefore it is proposed that LCN2 participates in the antibacterial iron depletion strategy of the innate immune system (Flo et al. 2004).
Reaction - small molecule participants:
Fe3+ [extracellular region]
Fe3+ [extracellular region]
Reactome.org reaction link: R-HSA-5229273
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Reaction input - small molecules:
iron(3+)
iron(3+)
Reaction output - small molecules:
Reactome.org link: R-HSA-5229273