Reaction: CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
- in pathway: Depolymerization of the Nuclear Lamina
Phosphorylation of the N-termini of lamins by CDK1 (serine S23 of lamin B, serin S22 of lamin A and C) probably happens consequentially with phosphorylation of C-termini of lamins by PKC, and contributes to the depolymerization of lamin filaments and solubilization of the nuclear lamina (Ward and Kirschner 1990, Peter et al. 1990, Heald and McKeon 1990, Mall et al. 2012).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5244669
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5244669