Reaction: botD HC:LC binds SV2A or B or C and GD2 on the target cell surface
- in pathway: Toxicity of botulinum toxin type D (botD)
The botulinum toxin type D disulfide-bonded heavy chain - light chain heterodimer ("dichain") (botD HC:LC, encoded by the C. botulinum botD gene) binds ganglioside GD2 and synaptic vesicle proteins 2A (SV2A), 2B (SV2B), or 2C (SV2C) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A, SV2B, or SV2C when those proteins are exposed at the cell surface by exocytosis (Kroken et al. 2011; Peng et al. 2011).
Reaction - small molecule participants:
GD2 [plasma membrane]
Reactome.org reaction link: R-HSA-5250607
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Reaction input - small molecules:
beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer
Reaction output - small molecules:
Reactome.org link: R-HSA-5250607