Reaction: botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol
- in pathway: Toxicity of botulinum toxin type D (botD)
By analogy to the process described for botulinum toxin type A (Koriazova and Montal 2003; Montal 2010), acidification, a normal step in synaptic vesicle recycling, is inferred to cause a conformational change in the botulinum toxin type D disulfide-bonded heavy chain - light chain dimer (botD HC:LC) it contains, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol where the HC - LC disulfide bond is cleaved.
Reaction - small molecule participants:
GD2 [synaptic vesicle membrane]
Reactome.org reaction link: R-HSA-5250616
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Reaction input - small molecules:
Reaction output - small molecules:
beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer
Reactome.org link: R-HSA-5250616