Reaction: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
- in pathway: B-WICH complex positively regulates rRNA expression
Histone acetyltransferases recruited by the B‑WICH complex acetylate histone H3 at lysine‑9. Knockdown of the BAZ1B (WSTF) and MYOIC components of B‑WICH cause a loss of histone acetyltransferases KAT2B (PCAF), KAT2A (GCN5), and EP300 (p300) and a reduction of acetylated histone H3. Knockdown of KAT2B (PCAF) causes a reduction in acetylation of histone H3 at lysine‑9, leading to reduced rRNA synthesis levels (Sarshad et al. 2013, Shen et al. 2013).
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-5250938
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Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-5250938