Reaction: HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
- in pathway: Regulation of HSF1-mediated heat shock response
Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. It is only able to bind HSP70s when they are bound to ATP. DnaJ homolog subfamily members (aka heat-shock 40 proteins, HSP40s) also translocate to the nucleus under heat-shock stress (Hattori et al. 1992) and can act as stimulators of intrinsic ATPase activity of HSP70s. The result is that Hikeshi dissociates from HSP70:ADP.
Reaction - small molecule participants:
Pi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5251955
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-5251955