Reaction: ATP13A4,5 transport divalent ions from extracellular region to cytosol
- in pathway: Ion transport by P-type ATPases
Probable cation-transporting ATPases 13A4 and 13A5 (ATP13A4, 5) belong to the P5 subfamily of P-tpre ATPases. This subfamily is the most poorly understood in terms of chracterisation and function. The yeast orthologue YPK9 (aka Yor291w) shows toxicity when deleted from yeast cells, suggesting a role in sequestration of divalent heavy metal ions (Schmidt et al. 2009). The ATP13A4 gene may be disrupted by a 3q25-q29 inversion of the long arm of chromosome 3, which may result in a specific language impairment (SLI) (Kwasnicka-Crawford et al. 2005).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
divalent metal cation [cytosol]
H2O [cytosol]
divalent metal cation [extracellular region]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5251989
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Reaction input - small molecules:
water
divalent metal cation
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
divalent metal cation
Reactome.org link: R-HSA-5251989