Reaction: MPI isomerises Fru6P to Man6P
- in pathway: Synthesis of GDP-mannose
Mannose-6-phosphate isomerase (MPI) isomerises fructose 6-phosphate (Fru6P) to mannose 6-phosphate (Man6P) (Proudfoot et al. 1994). Defects in this gene are associated with congenital disorder of glycosylation type 1B (CDG1B). Oral administration of mannose is an efficient therapy against this defect (Schollen et al. 2000).
Reaction - small molecule participants:
Man6P [cytosol]
Fru(6)P [cytosol]
Reactome.org reaction link: R-HSA-532549
======
Reaction input - small molecules:
beta-D-fructofuranose 6-phosphate(2-)
Reaction output - small molecules:
D-mannose 6-phosphate
Reactome.org link: R-HSA-532549