Reaction: Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase
After the glycosylated precursor is attached to the protein, the outer alpha-1,2-linked glucose is removed by by mannosyl-oligosaccharide glucosidase (MOGS, GCS1 in yeast). This is a mandatory step for the protein folding control and glycan extension, and defects in MOGS are associated with congenital disorder of glycosylation type IIb (CDGIIb) (De Praeter et al. 2000, Völker et al. 2002).
Reaction - small molecule participants:
Glc [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-532678
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Reaction input - small molecules:
Reaction output - small molecules:
alpha-D-glucose
Reactome.org link: R-HSA-532678