Reaction: 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
- in pathway: Selenocysteine synthesis
The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This triggers the hydrolysis of GTP (to GDP) by EEFSEC and delivery of Sec-tRNASec to the ribosomal A site. Before the Sec residue is inserted into the nascent polypeptide chain, EEFSEC:GDP is released. This reaction is inferred from events occurring in rats.
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-5333615
======
Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-5333615