Reaction: CLAT:AP1:CLVS bind PI(3,5)P2

- in pathway: Lysosome Vesicle Biogenesis
Clathrin-coated vesicles (CCVs) originating from the trans-Golgi network (TGN) provide a major transport pathway from the secretory system to endosomes/lysosomes. Clavesin 1 and 2 (CLVS1 and 2) are enriched on CCVs and form a complex with clathrin heavy chain (CHC) and adaptor protein-1 (AP1) complex, major coat components of TGN-derived CCVs. The complex can bind phosphatidylinositol 3,5-bisphosphate (PIP2), a phospholipid localised to late endosomes and lysosomes. This interaction is thought to assist the transport of cytosolic cargo proteins to the endosomal network (Katoh et al. 2009).
Reaction - small molecule participants:
PI(3,5)P2 [lysosomal membrane]
Reactome.org reaction link: R-HSA-5333658

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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
ChEBI:57923
Reaction output - small molecules:
Reactome.org link: R-HSA-5333658