Reaction: DT fragment A ADP-ribosylates target cell EEF
- in pathway: Uptake and function of diphtheria toxin
Target cell elongation factor 2 (EEF2) is ADP-ribosylated in a reaction catalyzed by cytosolic diphtheria toxin fragment A (DT A), inactivating it (Honjo et al. 1971; Van Ness et al. 1980a,b). The loss of EEF2 activity blocks target cell protein synthesis, and a small number of DT A molecules are capable of inactivating sufficient EEF2 to cause target cell death (Collier 1975).
Reaction - small molecule participants:
NAM [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5336421
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
Reactome.org link: R-HSA-5336421