Reaction: NIPAs transport Mg2+ from extracellular region to cytosol
- in pathway: Miscellaneous transport and binding events
Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporters NIPA1, 2, 3, 4 (NIPA1,2,3,4) and NIPA-like proteins 2 and 2 (NIPAL2 and 3) can act as Mg2+ transporters. They may also transport other divalent cations such as Fe2+, Mn2+ and Ba2+ but to a lesser extent than Mg2+. Human NIPA1 mediates Mg2+ uptake when expressed in Xenopus oocytes (Goytain et al. 2007). The other NIPA members are included as candidates based on NIPA1 function.
Reaction - small molecule participants:
Mg2+ [cytosol]
Mg2+ [extracellular region]
Reactome.org reaction link: R-HSA-5336453
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Reaction input - small molecules:
magnesium(2+)
Reaction output - small molecules:
magnesium(2+)
Reactome.org link: R-HSA-5336453