Reaction: GLTPD1 transports C1P from plasma membrane to Golgi membrane
- in pathway: Glycosphingolipid biosynthesis
Ceramide-1-phosphate transfer protein (GLTPD1) mediates the intracellular transfer of ceramide-1-phosphate (C1P) between the cell membrane and organelle membranes. C1P is an activator of group IVA cytosolic phospholipase (PLA2G4A), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, which contributes to disease pathogenesis. To avoid the effects of chronic inflammation, cells require efficient targeting, trafficking and presentation of C1P to specific cellular sites. GLTPD1 is localised in the cytosol but can associate with plamsa, Golgi and nuclear membranes (Simanshu et al. 2013).
Reaction - small molecule participants:
C1P [Golgi membrane]
C1P [plasma membrane]
Reactome.org reaction link: R-HSA-5339535
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Reaction input - small molecules:
N-acylsphingosine 1-phosphate
Reaction output - small molecules:
N-acylsphingosine 1-phosphate
Reactome.org link: R-HSA-5339535