Reaction: MAGT1 transports Mg2+ from extracellular region to cytosol
- in pathway: Miscellaneous transport and binding events
Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporter protein 1 (MAGT1) is ubiquitously expressed in all human tissues and is upregulated by low Mg2+ concentrations. It is an essential protein in Mg2+ uptake into cells (Zhou & Clapham 2009, Goytain & Quamme 2005).
Reaction - small molecule participants:
Mg2+ [cytosol]
Mg2+ [extracellular region]
Reactome.org reaction link: R-HSA-5339538
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Reaction input - small molecules:
magnesium(2+)
Reaction output - small molecules:
magnesium(2+)
Reactome.org link: R-HSA-5339538