Reaction: AXL autophosphorylates on Y779 and Y821
- in pathway: VEGFA-VEGFR2 Pathway
VEGFA-dependent activation of VEGFR2 causes autophosphorylation and activation of the Axl receptor tyrosine kinase via Src-1:SH2D2A-dependent reaction. Phosphorylation of Axl tyrosine residues 779 and 821 (773 and 815 in mouse) is required for VEGFA-dependent binding of the p85-subunit of PI3K and activation of PI3K (Ruan & Kazlauskas, 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5357429
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5357429