Reaction: DPH6 ligates ammonium to diphthine-EEF2
- in pathway: Synthesis of diphthamide-EEF2
Cytosolic diphthamide biosynthesis protein 6 (DPH6) ligates an ammonium ion to diphthine-EEF2 to generate diphthamide-EEF2 in a reaction coupled to the hydrolysis of ATP to yield AMP and PPi (Su et al. 2012; Uthman et al. 2013; Wei et al. 2013).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
NH4+ [cytosol]
Reactome.org reaction link: R-HSA-5358475
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Reaction input - small molecules:
ATP(4-)
ammonium
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-5358475